| 发明名称 |
METHODS FOR TREATING SUBJECTS WITH PRIMARY HYPERCHOLESTEROLEMIA THAT IS NOT ADEQUATELY CONTROLLED |
| 摘要 |
The present invention provides methods for treating hypercholesterolemia. The methods of the present invention comprise administering to a patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P. The methods of the present invention are useful for treating patients with hypercholesterolemia that is not adequately controlled by moderate-dose statin therapy. |
| 申请公布号 |
US2015283236(A1) |
申请公布日期 |
2015.10.08 |
| 申请号 |
US201514657186 |
申请日期 |
2015.03.13 |
| 申请人 |
Baccara-Dinet Marie;Hanotin Corinne;Harada Yuko;Sato Toshiaki;Suzuki Hideyo |
发明人 |
Baccara-Dinet Marie;Hanotin Corinne;Harada Yuko;Sato Toshiaki;Suzuki Hideyo |
| 分类号 |
A61K39/395;A61K45/06 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating hypercholesterolemia in a subject in need thereof, comprising:
a) selecting a subject who is currently being treated for hypercholesterolemia by administration of a background lipid-modifying therapy; b) continuing treating the subject with the background lipid-modifying therapy; and c) administering to the subject a pharmaceutical composition comprising about 75 mg of an antibody or antigen binding fragment thereof that specifically binds PCSK9 at a frequency of about once every other week (q2w), thereby treating the hypercholesterolemia in the subject. |
| 地址 |
Paris FR |
