发明名称 QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE
摘要 The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.
申请公布号 US2015283106(A1) 申请公布日期 2015.10.08
申请号 US201314437334 申请日期 2013.10.10
申请人 NICOX SCIENCE IRELAND 发明人 Ongini Ennio;Almirante Nicoletta;Storoni Laura
分类号 A61K31/21;A61K45/06;A61K31/341;A61K9/00 主分类号 A61K31/21
代理机构 代理人
主权项 1. A compound of formula (I) or stereoisomers thereof for use in treating hypertensive glaucoma, normotensive glaucoma, secondary glaucoma and ocular hypertension wherein R1 is selected from H, methyl, methoxy; R3 is selected from H, methyl, methoxy; or R1 and R3 together form —CH═CH—CH═CH—; R2 is H, methyl; n is an integer from 0 to 10; Q is selected from the group consisting of: wherein m is an integer from 0 to 6; p is an integer from 0 to 1; X is O, S or is —CHONO2, with the proviso that when X is —CHONO2 then m is 0.
地址 Dublin 2 IE