发明名称 |
Trans-Clomiphene for Use in Cancer Therapy |
摘要 |
The present invention relates to the administration of compositions comprising an antiestrogen, preferably a selective estrogen receptor modulator (SERM) such as trans-clomiphene, for treating cancer and associated diseases. The invention is also directed to methods for reducing IGF-1 levels in a subject in need thereof by administering a composition comprising an antiestrogen, preferably a SERM such as trans-clomiphene. |
申请公布号 |
US2015283099(A1) |
申请公布日期 |
2015.10.08 |
申请号 |
US201314440007 |
申请日期 |
2013.10.22 |
申请人 |
REPROS THERAPEUTICS INC. |
发明人 |
Podolski Joseph S.;Wiehle Ronald D.;Hsu Kuang;Fontenot Greg |
分类号 |
A61K31/138;A61K45/06 |
主分类号 |
A61K31/138 |
代理机构 |
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代理人 |
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主权项 |
1. A method for reducing the level of insulin-like growth factor-1 (IGF-1) in the serum of a subject with cancer and an elevated serum level of IGF-1 comprising administering to the subject of a composition comprising about 0% cis-clomiphene and about 100% trans-clomiphene or pharmaceutically acceptable salts or analogs thereof and a suitable carrier in an amount effective to reduce IGF-1 levels in the subject by at least 30%. |
地址 |
The woodlands TX US |