APPARATUS AND METHOD FOR NUCLEIC ACID SEQUENCING BASED ON NANOWIRE DETECTORS

摘要

An apparatus for nucleic acid sequencing includes: a base-detection device in a detection site, the base-detection device being configured to detect bases of a portion of a nucleic acid strand at the detection site; and a conveying device, configured to extend the nucleic acid strand and to cause the extended nucleic acid strand to slide through the detection site along a path. The base-detection device includes a plurality of field-effect nanowire detectors, arranged along the path and each including a respective nanowire and nucleic acid probes, which are defined by respective base sequences and are fixed to the respective nanowire.

主权项

1. An apparatus for nucleic acid sequencing, comprising:
a base-detection device in a detection site, the base-detection device being configured to detect bases of a portion of a nucleic acid strand at the detection site; and a conveying device configured to extend the nucleic acid strand and to cause the extended nucleic acid strand to slide through the detection site along a path; wherein the base-detection device comprises a plurality of field-effect nanowire detectors arranged along the path and each including a respective nanowire and nucleic acid probes, which are defined by respective base sequences and are fixed to the respective nanowire.