| 发明名称 |
ALTERED MICROBIOME OF CHRONIC PELVIC PAIN |
| 摘要 |
Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis). |
| 申请公布号 |
US2015284781(A1) |
申请公布日期 |
2015.10.08 |
| 申请号 |
US201514677239 |
申请日期 |
2015.04.02 |
| 申请人 |
Northwestern University ;The Board of Trustees of the University of Illinois |
发明人 |
Klumpp David J.;Schaeffer Anthony J.;White Bryan A. |
| 分类号 |
C12Q1/68;A61K35/741 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method comprising:
testing, or having tested a stool sample from a subject suspected of suffering from interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS), to determine the level of bacteria from at least one bacterial species from a bacterial genus, wherein said bacterial genus is selected from the group consisting of: Odoribacter, Faecalibacterium, Colinsella, Eggerthella, Lactonifactor, and Roseburia. |
| 地址 |
Evanston IL US |
