| 发明名称 |
METHOD OF ISOLATING SYNAGIS(R) IN THE ABSENCE OF BENZONASE |
| 摘要 |
The present invention is directed to method of isolating an antibody from a composition. In some embodiments, the method comprises isolating Synagis® from a composition comprising Synagis®, the method comprising: (i) performing an ion exchange chromatography process on the composition; (ii) performing an affinity purification process on the composition; and (iii) performing a filtration process on the composition, wherein a final product comprising Synagis® results from (i), (ii), and (iii), wherein the final product is suitable for administration to a human and has a DNA concentration of <0.5 pg/mg, and wherein the method does not comprise adding benzonase to the composition. |
| 申请公布号 |
US2015284447(A1) |
申请公布日期 |
2015.10.08 |
| 申请号 |
US201314440640 |
申请日期 |
2013.11.05 |
| 申请人 |
MEDIMMUNE, LLC |
发明人 |
Wan Min;Forespring Christopher;Lapcevich Randall;Shane Erica;Oliver Cynthia |
| 分类号 |
C07K16/10;C07K16/06 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of isolating Synagis® from a composition comprising Synagis®, the method comprising:
i. performing an ion exchange chromatography process on the composition; ii. performing an affinity purification process on the composition; and iii. performing a filtration process on the composition;wherein a final product comprising Synagis® results from (i), (ii), and (iii), wherein the final product is suitable for administration to a human and has a DNA concentration of ≦0.5 pg/mg, and wherein the method does not comprise adding benzonase to the composition. |
| 地址 |
Gaithersburg MD US |
