SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS

摘要

The present invention is directed to secondary alcohol substituted triazole compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

主权项

1. A compound of the formula I:wherein:
A represents R represents H or C1-6alkyl; R1 is selected from the groups consisting of (CH2)nC1-4haloalkyl, C1-6alkyl, C3-6cycloalkyl, C6-10 aryl , said alkyl cycloalkyl, and aryl is unsubstituted or substituted with 1 to 3 groups of Ra; R2 is selected from the group consisting of H, O—R, CN, O(CH2)nOR, OCHR(CH2)nOR, SR, SO2R, S(O)R, N(R)2, C(O)N(R)2, C1-3 haloalkyl, O(CH2)nC1-3haloalkyl, O(CH2)nC3-6cycloalkyl, (CH2)nC5-10heterocycle, C1-6alkyl, and C3-10cycloalkyl, said alkyl, cycloalkyl, and heterocycle is unsubstituted or substituted with 1 to 3 groups of Ra; Ra is selected from the group consisting of: (1) halogen, (2) hydroxyl, (3) C1-6alkyl, (4) —(CH2)nO—R, (5) (CH2)n C6-10aryl, (6) (CH2)nC5-10 heterocycle, (7) OC1-5 haloalkyl; (8) CO2R; (9) C(O)N(R)2; (10) (CH2)nC(O)R; (11) CN, (12) (CH2)nN(R)2; (13) (CH2)nC3-6cycloalkyl, (14) (CH2)nC1-3 haloalkyl; n represents 0-4, or a pharmaceutically acceptable salt thereof.