发明名称 |
SELECTION SYSTEM FOR EUKARYOTIC CELL CULTURE BASED ON A MEMBRANE-BOUND FOLATE RECEPTOR GENE |
摘要 |
<p>The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake.</p> |
申请公布号 |
PT2227549(E) |
申请公布日期 |
2015.10.08 |
申请号 |
PT20080865304T |
申请日期 |
2008.12.19 |
申请人 |
NOVARTIS AG |
发明人 |
THOMAS JOSTOCK;HANS-PETER KNOPF;YEHUDA G. ASSARAF |
分类号 |
C12N15/85;C07K14/705;C12N5/16 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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