| 发明名称 |
ORGANIC COMPOSITIONS TO TREAT HSF1-RELATED DISEASES |
| 摘要 |
The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF. |
| 申请公布号 |
US2015284721(A1) |
申请公布日期 |
2015.10.08 |
| 申请号 |
US201514746148 |
申请日期 |
2015.06.22 |
| 申请人 |
ARROWHEAD RESEARCH CORPORATION |
发明人 |
HINKLE Gregory;KUCHIMANCHI Satyanarayana;MILSTEIN Stuart;WARMUTH Markus;ZHOU Wenlai;ZHU Ping;ZIMMERMANN Tracy S. |
| 分类号 |
C12N15/113;A61K31/713;A61K45/06 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising an RNAi agent to HSF1 comprising a first strand and a second strand, wherein the sequence of the first strand comprises at least 15 contiguous nucleotides of any sequence disclosed in Table A1, wherein the first and/or second strand are modified or unmodified, and wherein the first and/or second strand are no more than about 49 nt long. |
| 地址 |
Pasadena CA US |
