GRANULE COMPRISING SILODOSIN, AND PHARMACEUTICAL COMPOSITION AND FORMULATION COMPRISING SAME

摘要

The present invention relates to a granule comprising silodosin; alkaline inorganic salt as a stabilizer; and a pharmaceutically acceptable excipient. The present invention shows that the inventive granules exhibit improved stability for silodosin, and reduction in unwanted reaction of silidosin with other excipients. Thus, the granule comprising silidosin of the present invention can be used for the development of a composition or formulation with a variety of dissolution characteristics, without any influence to the stability of silodosin. Also, owing to the decreased adverse effects which may result from degradation products of silodosin, it can be utilized as a safer therapeutic agent for prostatic hypertrophy.