发明名称 |
USE OF DOUBLE-STRANDED DNA IN EXOSOMES: A NOVEL BIOMARKER IN CANCER DETECTION |
摘要 |
<p>The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double- stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.</p> |
申请公布号 |
WO2015153732(A2) |
申请公布日期 |
2015.10.08 |
申请号 |
WO2015US23832 |
申请日期 |
2015.04.01 |
申请人 |
CORNELL UNIVERSITY;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
LYDEN, DAVID, C.;SELGAS, HECTOR, PEINADO;ZHANG, HAIYING;THAKUR, BASANT, KUMAR;BECKER, ANNATTE;BROMBERG, JACQUELINE |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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