ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide antibodies that specifically bind to tissue factor pathway inhibitor and reduce clotting time of blood.SOLUTION: The invention provides monoclonal antibodies that specifically bind to Kunitz 2 (K2) domain of TFPI, which antibodies specifically bind to an epitope of the domain comprising specified residues. Such an antibody can neutralize TFPI inhibition of membrane bound FVIIa/TF/FXa by at least 55% as measured in an FVIIa/TF/FXa inhibitor assay, when TFPI is saturated with the antibody. Such antibodies have utility in the treatment of subjects with a coagulopathy.