发明名称 |
METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT AND PREVENTION OF AGENT-INDUCED GONADAL OR UTERINE TOXICITY |
摘要 |
A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium- derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo. |
申请公布号 |
WO2015151091(A1) |
申请公布日期 |
2015.10.08 |
申请号 |
WO2015IL50340 |
申请日期 |
2015.03.30 |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD.;MOR RESEARCH APPLICATIONS LTD. |
发明人 |
SHALGI, RUTH;CHUDERLAND, DANA;BAR-JOSEPH, HADAS;GOLDBERG, KEREN;BEN-AHARON, IRIT;STEMMER, SALOMON M. |
分类号 |
A61K38/18;A61K31/138;A61P15/08 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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