METHOD FOR THE PREPARATION OF BIOLOGICAL TISSUE FOR DRY USE IN AN IMPLANT

摘要

A method of preparing biological tissue for use as a component of an implant, in particular as part of a heart valve prosthesis, which can be implanted by catheter. The biological tissue is subjected to a dimensional and structural stabilization step and is dried. For the dimensional and structural stabilization, a combination of a first, polyethylene glycol-containing solution and at least one second, glycerol-containing solution is used.

主权项

1. A method of preparing biological tissue for use as a component of a heart valve prosthesis comprising pretreating the tissue, stabilizing the pretreated tissue and optionally drying the stabilized tissue, characterized in that, the step of pretreating the tissue comprises crosslinking the tissue with an aldehyde-containing solvent, wherein the aldehyde is glutaraldehyde or formaldehyde; and the step of stabilizing the pretreated tissue comprises exposing the tissue to a first solution and a second solution for dimensional and structural stabilization, wherein the first solution contains polyethylene glycol and the second solution contains glycerol, wherein the tissue is exposed to the first and second solutions one after the other in any order or is exposed to both solutions simultaneously as a solution mixture.