发明名称 |
PHARMACOPHORE FOR TRAIL INDUCTION |
摘要 |
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein. The invention is directed, in various embodiments, to a compound and pharmaceutical composition comprising an effective amount of a compound capable of inducing expression of TRAIL gene in cells capable of expressing the TRAIL gene to produce the cytokine TRAIL. |
申请公布号 |
WO2015153468(A1) |
申请公布日期 |
2015.10.08 |
申请号 |
WO2015US23362 |
申请日期 |
2015.03.30 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
JANDA, KIM D.;JACOB, NICHOLAS T.;LOCKNER, JONATHAN W. |
分类号 |
A61K31/519 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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