NOVEL LIPOSOMAL FORMULATIONS THAT FORM DRUG NANOCRYSTALS AFTER FREEZE-THAW

摘要

Methods for formulating a liposome comprised of a surfactant and a cryopreservative that can be frozen for long term stability, and upon thawing provides an immediate and sustained release delivery profile. Specific liposome formulations include anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

主权项

1. A formulation, comprising:
liposomes wherein the liposomes comprise: a lipid bilayer; and a cryopreservative; nanocrystals of a pharmaceutically active drug surrounded by the lipid bilayer wherein the nanocrystals have dimensions of 200 nm or less.