发明名称 |
NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT |
摘要 |
The present invention provides for novel acridine-like class of compounds that have demonstrated efficiency in treating cancer. The compounds of the present invention have demonstrated efficacy in binding to and antagonizing the activity of the p53 repressor, HDMX. Once administered to a cell, the compounds of the present invention bind HDMX, thereby allowing p53 to induce apoptosis of the cancerous cell. A combination of this class of compounds along with Nutlin3 provides a novel approach to treat cancers. |
申请公布号 |
WO2015153535(A1) |
申请公布日期 |
2015.10.08 |
申请号 |
WO2015US23462 |
申请日期 |
2015.03.31 |
申请人 |
MIRX PHARMACEUTICALS, LLC |
发明人 |
WALD, DAVID;AGARWAL, MUKESH;XIA, ZHIQING;KARAN, GOUTAM |
分类号 |
A61K31/473 |
主分类号 |
A61K31/473 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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