SAQUINAVIR-NO FOR IMMUNOMODULATION

摘要

The nitric ester of Saquinavir, or its non-toxic salts, solvates or crystalline/polymorphic forms, I useful in the treatment of autoimmune diseases, particularly in disease mediated by pro-inflammatory cytokines. Examples of diseases which may be treated include idiopathic Addison's disease, autoimmune hepatitis, biliary cirrhosis, primary sclerosing cholangitis, Guillain Barré syndrome, Hashimoto's thyroiditis, psoriasis, rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematous, Type 1 diabetes mellitus and uveitis of ischemia-reperfusion, graft versus host diseases, graft rejection, endo and exo-toxemia and gouty arthritis.

主权项

1. Method of treating autoimmune diseases in patients in need thereof, said method comprising
administering an effective amount of nitric ester of Saquinavir, of its non-toxic salts, solvates or crystalline/polymorphic forms to said patients; and treating said autoimmune diseases in said patients.