METHODS OF TREATING PATIENTS INFECTED WITH HIV AND HTLV

摘要

Disclosed is a method of activating protein kinase C theta (PKCθ) in an HIV or HTLV infected animal comprising administering to the animal an effective amount of a compound of formula (I): Formula (I), or an epimer thereof; wherein Ar and R1-R6 are described herein. Examples of diseases or conditions associated with PKCθ include HIV1 infection, AIDS, HTLV infection, and adult T cell leukemia/lymphoma.;

主权项

1. A method of treating an HIV-infected animal or an HTLV-infected animal, increasing the activity of latent infected CD4+ cells of an animal carrying HIV, in inhibiting Treg activation and number in an animal carrying HTLV, and/or in decreasing Glut1 expression in an ATL cell in an animal carrying HTLV, comprising administering to the mammal a compound of formula (I): or an epimer thereof; wherein Ar is an aryl group, optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, halo, and nitro; X is O, NH, or S; R2 and R3 are independently C1-C6 alkyl; R1 is isopropyl or isopropenyl; “a” is a single bond or a double bond;
when “a” is a double bond, R4 is hydrogen, and R5 is halo or H;when “a” is a single bond, R4 is selected from the group consisting of halo, hydroxy, and C1-C6 alkoxy and R5 is halo or H; and R6 is H, C1-C6 alkyl carbonyl, or hydroxy C1-C6 alkyl carbonyl, with at least one antiviral agent.