| 发明名称 |
POLYMERIC NANOPARTICLES |
| 摘要 |
The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles. |
| 申请公布号 |
US2015283254(A1) |
申请公布日期 |
2015.10.08 |
| 申请号 |
US201314438596 |
申请日期 |
2013.10.28 |
| 申请人 |
VANDERBILT UNIVERSITY |
发明人 |
Duvall Craig L.;Nelson Christopher E.;Kintzing James;Shannon Joshua M.;Gupta Mukesh K.;Guelcher Scott A.;Adolph Elizabeth J.;Davidson Jeffrey M. |
| 分类号 |
A61K47/48;C12N15/113;A61K48/00;C08F283/06 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nanoparticle, comprising:
a plurality of polymers that include:
a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle; anda second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle; and a polynucleotide that is bound to the cationic monomers. |
| 地址 |
Nashville TN US |
