摘要 |
PROBLEM TO BE SOLVED: To provide formulations containing a low dose of entecavir, capable of being administered once a day to treat hepatitis B virus infection and/or co-infections.SOLUTION: This invention relates to the use of entecavir for the preparation of pharmaceutical compositions in the form of a tablet having 100 mg total weight. In a formulation containing the entecavir, the pharmaceutical compositions comprise 0.01% entecavir, 93.24% microcrystalline cellulose, 4.0% crospovidone, 2.50% povidone, and 0.25% magnesium stearate, the percentages being on a weight/weight basis, or comprise 1.0% entecavir, 90.0% mannitol, 4.0% croscarmellose sodium, 2.50% methyl cellulose, and 2.50% stearic acid. |