| 发明名称 |
SUBSTITUTED TRIAZOLE AND IMIDAZOLE COMPOUNDS |
| 摘要 |
<p>The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.</p> |
| 申请公布号 |
EP2925746(A1) |
申请公布日期 |
2015.10.07 |
| 申请号 |
EP20130796097 |
申请日期 |
2013.11.29 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
LYNCH, STEPHEN M.;MARTIN, RAINER E.;NEIDHART, WERNER;PLANCHER, JEAN-MARC;SCHULZ-GASCH, TANJA |
| 分类号 |
C07D403/12;A61K31/415;A61K31/4164;A61K31/4192;A61K31/4196;A61P1/00;A61P19/02;C07D233/90;C07D249/04;C07D249/10;C07D401/12;C07D403/06;C07D405/12;C07D409/12 |
主分类号 |
C07D403/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
