| 发明名称 | Barrier layer for glucose sensor | ||
| 摘要 | An optical glucose sensor comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a hydrophilic, polymeric, glucose-permeable barrier layer which is provided on at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through said barrier layer. | ||
| 申请公布号 | US9151764(B2) | 申请公布日期 | 2015.10.06 |
| 申请号 | US201113578893 | 申请日期 | 2011.02.15 |
| 申请人 | Lightship Medical Limited | 发明人 | Crane Barry Colin;Paterson William;Culbert Bruce |
| 分类号 | G01N33/66;B01D63/00;A61B5/145;A61B5/1459;G01N21/77 | 主分类号 | G01N33/66 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. An optical glucose sensor comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a hydrophilic, polymeric, glucose-permeable barrier layer which is provided on at least a part of the sensing region, the barrier layer comprising a semi-permeable membrane having a polymer which incorporates a negative charge within the pores of the membrane, the membrane being formed by generating the polymer in situ by diffusing a monomer incorporating a negative charge into the pores of a membrane and initiating polymerisation;wherein the sensor is adapted so that glucose enters the sensing region of the sensor through said barrier layer, and wherein the polymer which incorporates a negative charge does not comprise a boronic acid receptor or a fluorophore. | ||
| 地址 | London GB | ||