发明名称 |
Crystal form of (6S)-5-methyltetrahydrofolate salt and method for preparing same |
摘要 |
Disclosed are a crystal form of (6S)-5-methyltetrahydrofolate salt and a method for preparing the same. The crystal form is: Form C of the crystal form of (6S)-5-methyltetrahydrofolate calcium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.3±0.2 and 19.2±0.2; or the crystal form of (6S)-5-methyltetrahydrofolate strontium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.5±0.2 and 22.0±0.2. The crystal form of (6S)-5-methyltetrahydrofolate salt of the present invention has the advantages of excellent physicochemical properties, good stability, high purity, good reproducibility, and being more suitable for production on an industrial scale. |
申请公布号 |
US9150982(B2) |
申请公布日期 |
2015.10.06 |
申请号 |
US201214373262 |
申请日期 |
2012.12.17 |
申请人 |
LIANYUNGANG JINKANG HEXIN PHARMACEUTICAL CO. LTD. |
发明人 |
Wang Zheqing;Cheng Yongzhi;Huang Heng;Li Huizhen |
分类号 |
C07D475/04;C30B30/06;A23L1/30;A61K31/519;C30B7/14;C30B29/54;A23L1/303 |
主分类号 |
C07D475/04 |
代理机构 |
Osha Liang LLP |
代理人 |
Osha Liang LLP |
主权项 |
1. A crystal form of (6S)-5-methyltetrahydrofolate salt, wherein the crystal form is:
(a) Form C of the crystal form of (6S)-5-methyltetrahydrofolate calcium salt, wherein the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 3.2±0.2, 6.3±0.2, 13.2±0.2, 14.6±0.2, 19.2±0.2 and 32.6±0.2. |
地址 |
Jiangsu CN |