| 发明名称 | Prodrugs of fluorinated mevalonates to inhibit the mevalonate pathway of <i>Streptococcus pneumoniae</i> | ||
| 摘要 | Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition. | ||
| 申请公布号 | US9150534(B2) | 申请公布日期 | 2015.10.06 |
| 申请号 | US201313780929 | 申请日期 | 2013.02.28 |
| 申请人 | Northwestern University;Albert Einstein College of Medicine of Yeshiva University | 发明人 | Silverman Richard B.;Watanabe Mizuki;Kang Soosung;Leyh Thomas S. |
| 分类号 | C07D321/00;C07D309/30;C07D319/06;C07C69/675;C07C235/06 | 主分类号 | C07D321/00 |
| 代理机构 | Reinhart Boerner Van Deuren s.c. | 代理人 | Reinhart Boerner Van Deuren s.c. |
| 主权项 | 1. A compound of a formula wherein X is selected from NH, O and S; R1 is selected from mono- and polyfluoro-substituted methyl moieties; and R2 is selected from alkyl, mono- and polyfluoro-substituted alkyl, alkanoyloxy, cycloalkyl, mono- and polyfluoro-substituted cycloalkyl, aryl, mono- and polyfluoro-substituted aryl, arylalkyl, and mono- and polyfluoro-substituted arylalkyl moieties. | ||
| 地址 | Evanston IL US | ||