Suppression of cancer growth and metastasis using nordihydroguaiaretic acid derivatives with metabolic modulators

摘要

Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two metabolic modulators. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis.

主权项

1. A pharmaceutical anti-tumor composition comprising a synergistically effective amount of a derivative of nordihydroguaiaretic acid (NDGA) comprising tetra-o-methyl nordihydroguaiaretic acid (M4N) or maltose-M3N and a synergistically effective amount of a metabolic modulator, wherein the metabolic modulator is selected from the group consisting of Ly294002, rottlerin, dichloroacetate, and rapamycin.