Polyvalent conjugate vaccine for cancer

摘要

This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. This invention also provides a multivalent vaccine comprising at least two of the following: glycosylated MUC-1-32mer, Globo H, GM2, Ley, Tn(c), sTN(c), and TF(c). This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant. This invention provides a method for inducing immune response in a subject comprising administering an effective amount of the vaccine above to the subject. Finally, this invention provides a method for treating cancer in a subject comprising administering an appropriate amount of the vaccine above to the subject.

主权项

1. A method for inducing antibody production in a subject comprising administering an immunogenic composition comprising an adjuvant and antigens comprising MUC1-Tn conjugate, GloboH, TF(c) and at least one antigen selected from the group consisting of GM2, sTn(c) and sialyl Lea, wherein said conjugate and each of said antigens are individually conjugated to a carrier.