Methods and compositions of treating a <i>Flaviviridae </i>family viral infection

摘要

Briefly described, embodiments of this disclosure include compounds (e.g., such as Formula II, Formula II-a, and specific compounds shown in Table 1), pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.

主权项

1. A method of treating a subject infected with a virus from the Flaviviridae family, the method comprising administering to said subject an indazole compound, or a pharmaceutically acceptable salt, in an amount that is effective in reducing viral load of said virus in said subject, wherein the indazole compound is a compound of Formula II-a, or a pharmaceutically acceptable salt: wherein R1 is selected from the group consisting of: —H andwherein V is selected from the group consisting of alkyl, cycloalkyl, heterocyclo, aryl, and heteroaryl, wherein V is optionally substituted or unsubstituted;
R3 is selected from the group consisting of —H, —OH, —O(CH2)nX, or —(CH2)nX, wherein n is 1, 2, 3, or 4, and X is selected from the group consisting of —NH2, —NH(alkyl), —N(alkyl)2, —OH, —O-alkyl, —O-aryl, —SO2(alkyl), —SO2NH2, —SO2NH(alkyl), NHSO2(alkyl), heteroaryl, N-attached heterocyclo, and C-attached heterocyclo; each of R4-R7 is independently selected from the group consisting of: —H, —Br, —Cl, —F, —I, —CH3, —CN, —OH, —OCH3, —NO2, —NH2, —NHCO(alkyl), —NHCO(aryl), or optionally, R4 and R5, R5 and R6, or R6 and R7 are joined together with a bond to form a 5, 6, or 7-membered ring; or, optionally, R4 and R5, R5 and R6, or R6 and R7 are joined together to form a 1,2-(methylenedioxy)benzene ring system.