| 发明名称 |
INTERLEUKIN-12P40 VARIANTS WITH IMPROVED STABILITY |
| 摘要 |
<p>Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.</p> |
| 申请公布号 |
CA2635618(C) |
申请公布日期 |
2015.10.06 |
| 申请号 |
CA20062635618 |
申请日期 |
2006.12.20 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAEKTER HAFTUNG |
发明人 |
WEBSTER, GORDON D.;MCKENZIE, SUZANNE P.;LO, KIN-MING;STEIN, PASCAL ANDRE |
| 分类号 |
C07K14/54;A61K38/20;C12N5/00;C12N15/24;C12N15/62 |
主分类号 |
C07K14/54 |
| 代理机构 |
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