siRNA targeting VEGFA and methods for treatment in vivo

摘要

Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression.

主权项

1. A pharmaceutical composition comprising a therapeutically effective amount of an siRNA, wherein the siRNA consists essentially of:
(a) an antisense strand that is nineteen to thirty-six bases in length and that has a sequence that comprises SEQ ID NO: 54; and (b) a sense strand that is nineteen to thirty-six bases in length, wherein the antisense strand and the sense strand form a duplex region of seventeen to thirty base pairs and within the duplex region are at least 75% complementary.