| 发明名称 | Anti-ASIC1 antibodies and uses thereof | ||
| 摘要 | The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. | ||
| 申请公布号 | US9150648(B2) | 申请公布日期 | 2015.10.06 |
| 申请号 | US201313753836 | 申请日期 | 2013.01.30 |
| 申请人 | Regeneron Pharmaceuticals, Inc. | 发明人 | MacDonald Lynn;Gao Min;Morra Marc R.;Alessandri-Haber Nicole M.;LaCroix-Fralish Michael L. |
| 分类号 | A61K39/395;C07K16/28;C07K16/18;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Swanson & Bratschun, L.L.C. | 代理人 | Swanson & Bratschun, L.L.C. |
| 主权项 | 1. An isolated antibody or antigen-binding fragment thereof that specifically binds cell surface-expressed acid sensing ion channel 1 (ASIC1) (SEQ ID NO:401), as measured using a fluorometric imaging plate reader (FLIPR) assay, wherein the antibody or antigen-binding fragment comprises: (a) three complementarity determining regions (CDRs) of a heavy chain variable region (HCVR) having the amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 34, 50, 66, 114, 130, 146, 162, 194, 210, 242, 258, and 274; and (b) three CDRs of a light chain variable region (LCVR) having the amino acid sequence selected from the group consisting of SEQ ID NOs: 10, 42, 58, 74, 122, 138, 154, 170, 202, 218, 250, 266, and 282. | ||
| 地址 | Tarrytown NY US | ||