Triazine derivative and pharmaceutical composition comprising the same

摘要

The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist.;A compound represented by the formula (I):;wherein Ra, Rb and Rc are,(a) Ra and Rb are taken together ═Z; and Rc is a group represented by R1c; or(b) Rb and Rc are taken together to form a bond; and Ra is a group represented by —Y—R1a;R1a and R1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.;R2 and R3 are each independently substituted or unsubstituted aryl, etc.;R4a and R4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.;X is —N(R5)—, etc.;R5 is hydrogen, substituted or unsubstituted lower alkyl, etc.;—Y— is —O—, etc.;═Z is ═O, etc.; andn is an integer of 0 to 4.

主权项

1. A compound represented by formula (II): or a pharmaceutically acceptable salt thereof, wherein R1c is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted acyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4a and R4b are each independently hydrogen; —X— is N(R5)—; R5 is hydrogen; ═Z is ═O; n is an integer of 1 to 2; R2 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is a group represented by the formula: wherein ring A is aryl or heteroaryl; s is an integer of 0 to 3; and R9 is each independently halogen, hydroxy, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy.