Local cochlear application of statins for stimulating neurite regrowth in the cochlea

摘要

Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear and methods for preventing damage to or treating damage of auditory neurons and/or hair cells of the cochlea following acoustic or toxic insult.

主权项

1. A method of stimulating neurite growth from spiral ganglion neurons in the inner ear, comprising contacting a neurite with a statin, or a pharmaceutically acceptable salt thereof, wherein the statin comprises a compound selected from a group consisting of compounds having formulas (II)-(VII):