Amine derivative having NPY Y5 receptor antagonistic activity

摘要

This invention provides a compound of the formula (I):;
a pharmaceutically acceptable salt or solvate thereof,

wherein

R1 is optionally substituted lower alkyl,

Y is —S(O)n— wherein n is 1 or 2, or —CO—,

R2 is hydrogen or lower alkyl,

R7 is hydrogen or lower alkyl,

X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, and

Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like.

主权项

1. A compound of a formula: or a pharmaceutically acceptable salt thereof, wherein R1 is optionally substituted lower alkyl, Y is —S(O)2-, R2 is hydrogen or optionally substituted lower alkyl, R7 is hydrogen or optionally substituted lower alkyl, X is a group of a formula: wherein R3 and R4 are each independently hydrogen, a group of a formula: is optionally substituted 1,4-cyclohexanediyl, p is 1 or 2, q is 0, and provided that a group of a formula: is not a group of a formula: wherein R14 is optionally substituted phenyl, and Z is optionally substituted phenyl, optionally substituted quinolyl, optionally substituted isoquinolyl, optionally substituted benzothiazolyl, optionally substituted benzimidazolyl, optionally substituted benzoxazolyl, optionally substituted thiazolopyridyl, optionally substituted oxazolopyridyl or optionally substituted pyrazolyl.