Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof

摘要

The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

主权项

1. An isolated antibody or an immunoreactive fragment thereof, wherein said isolated antibody or said fragment thereof comprises a variable domain that specifically binds an extracellular domain of B7-H3, wherein said antibody or said fragment thereof comprises a variable domain that comprises the amino acid sequences of:
(A) CDR1 (SEQ ID NO: 5), CDR2 (SEQ ID NO: 7) and CDR3 (SEQ ID NO: 9) of the light chain of BRCA84D; or (B) CDR1 (SEQ ID NO: 13), CDR2 (SEQ ID NO: 15) and CDR3 (SEQ ID NO: 17) of the heavy chain of BRCA84D.