Ingestible event markers comprising an ingestible component

摘要

Ingestible event markers comprising an identifier and an ingestible component are provided. The ingestible component may vary, where ingestible components of interest include osmotic ingestible components, liquid capsules, tablets, multi-layered ingestible component and multi-compartment ingestible components. In some instances, the identifier is mechanically stably associated with the ingestible component. Also provided are systems that include the ingestible event markers, as well as methods of using the ingestible event markers.

主权项

1. A device comprising:
an ingestible event marker comprising:
an identifier circuitry component that transmits a conductive signal through a body as a conductive medium when activated, where the conductive signal forms a current signature that identifies the ingestible event marker;a first electrochemical material electrically coupled to the identifier circuitry component;a second electrochemical material electrically coupled to the identifier circuitry at a different location from the first electrochemical material, where the second electrochemical material is dissimilar from the first electrochemical material such that the first and second electrochemical materials provide a voltage potential difference when in contact with a conductive fluid to power the identifier circuitry component and cause the identifier circuitry component to transmit a conductive signal through the conductive fluid; andan electrically insulative signal amplification element disposed between the first electrochemical material and the second electrochemical material, that extends beyond outer edges of the first electrochemical material and the second electrochemical material, such that the electrically insulative signal amplification element is configured to define a current path about the electrically insulative signal amplification element that is greater than a distance between the first electrochemical material and the second electrochemical material; and an osmotic ingestible component attached to the ingestible event marker, the osmotic ingestible component configured to provide the conductive fluid to the identifier circuitry of the ingestible event marker.