发明名称 |
Polymers and the preparation of nanogel drug cocktails |
摘要 |
Methods for forming, modifying, and drug loading of a copolymer are provided, along with the resulting products. The method can include polymerizing 2-(pyridin-2-yldisulfanyl)ethyl acrylate with poly(ethylene glycol)methacrylate via free radical polymerization to form the copolymer. The molar ratio of 2-(pyridin-2-yldisulfanyl)ethyl acrylate to poly(ethylene glycol)methacrylate is about 100:1 to about 1:100. After polymerizing, the copolymer can be reacted with a thiol monomer that contains a carbon-bonded sulfhydryl to modify end groups on a first portion of the 2-(pyridin-2-yldisulfanyl)ethyl acrylate repeating units. Thereafter, the copolymer can be crosslinked, and a drug can then be loaded into the crosslinked copolymer. |
申请公布号 |
US9149535(B2) |
申请公布日期 |
2015.10.06 |
申请号 |
US201313929981 |
申请日期 |
2013.06.28 |
申请人 |
University of South Carolina |
发明人 |
Xu Peisheng;Bahadur K.C. Remant |
分类号 |
A61K47/42;A61K47/32;C08F216/04;C08F8/34;C08F226/06;A61K9/51;A61K47/48;C08F8/04 |
主分类号 |
A61K47/42 |
代理机构 |
Dority & Manning, P.A. |
代理人 |
Dority & Manning, P.A. |
主权项 |
1. A method of forming a copolymer, the method comprising:
polymerizing 2-(pyridin-2-yldisulfanyl)ethyl acrylate with poly(ethylene glycol)methacrylate via free radical polymerization to form the copolymer, wherein the copolymer comprises 2-(pyridin-2-yldisulfanyl)ethyl acrylate repeating units and poly(ethylene glycol)methacrylate repeating units, and wherein the molar ratio of 2-(pyridin-2-yldisulfanyl)ethyl acrylate to poly(ethylene glycol)methacrylate is about 100:1 to about 1:100. |
地址 |
Columbia SC US |