P97-antibody conjugates and methods of use

摘要

The present invention provides p97-antibody conjugates and related compositions and methods, which may be used in any of a variety of therapeutic methods, including methods for the treatment of cancers such as Her2/neu-expressing and Her1/EGFR-expressing cancers.

主权项

1. A conjugate comprising a p97 polypeptide covalently or operatively linked to an antibody or antigen-binding fragment thereof that specifically binds the human Her2/neu protein, wherein the p97 polypeptide is a soluble p97 polypeptide that has a deletion of all or a portion of the hydrophobic domain as defined by residues 710-738 of SEQ ID NO: 1, and where the p97 polypeptide is effective for transporting the anti-Her2/neu antibody across the blood brain barrier.