Method for carrying out reactions in an analytical device

摘要

Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.

主权项

1. A method for carrying out heterogeneous chemical or biological reactions, the method comprising:
providing an analytical device comprising at least one liquid processing unit, the at least one liquid processing unit comprising at least one reaction chamber and a first inlet channel in fluid communication with a corner of the at least one reaction chamber; providing analyte capturing particles in the at least one reaction chamber; supplying to the at least one reaction chamber via the first inlet channel or a second inlet channel a liquid sample containing an analyte of interest; confining by an equilibrium of forces and geometry of the at least one reaction chamber and the first inlet channel the analyte capturing particles in a particle rearrangement zone within the at least one reaction chamber, the forces comprising a drag force Fd, generated by liquids flowing through the first inlet channel by centrifugal forces or generated by liquids flowing induced by Euler forces within the reaction chamber, and a counter-oriented force Fg induced by a centrifugal force; and capturing analytes present in the liquid sample with the analyte capturing particles in the particle rearrangement zone.