| 发明名称 | Anti-C-met antibody and methods of use thereof | ||
| 摘要 | Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc. | ||
| 申请公布号 | US9150655(B2) | 申请公布日期 | 2015.10.06 |
| 申请号 | US201113818283 | 申请日期 | 2011.08.30 |
| 申请人 | ACADEMIA SINICA | 发明人 | Wu Han-Chung;Lu Ruei-Min |
| 分类号 | C07K16/28;A61K9/127;A61K47/48;A61K49/00;A61K9/00;A61K47/24;A61K39/00 | 主分类号 | C07K16/28 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Bozicevic, Field & Francis LLP ;Sherwood Pamela J. |
| 主权项 | 1. An isolated monoclonal antibody that binds to human c-Met, comprising: a heavy chain variable region wherein the variable region comprises as a CDR1 the sequence of SEQ ID NO:10; as a CDR2 the sequence of SEQ ID NO:12, and as a CDR3 the sequence of SEQ ID NO:22; and a light chain variable region wherein the variable region comprises as a CDR1 the sequence of SEQ ID NO:31, as a CDR2 the sequence of SEQ ID NO:33, and as a CDR3 the sequence of SEQ ID NO:43. | ||
| 地址 | Nankang, Taipei TW | ||