Method and composition for reducing appearance of wrinkles

摘要

The present invention provides a cosmetic composition having a cosmetically acceptable vehicle and one or more gap junction inhibitors and/or one or more choline acetyl transferase (CAT) inhibitors in an amount effective for reducing the appearance of deep wrinkles on the skin. Also provided is a method of reducing the appearance of deep wrinkles on the skin, including the steps of topically applying to the skin the above cosmetic composition in an amount and for a period of time sufficient to reduce the appearance of deep wrinkles on the skin.

主权项

1. A method of reducing the appearance of wrinkles on skin of a person in need thereof, comprising: topically applying to wrinkles a composition comprising a cosmetically acceptable vehicle and an effective amount of:
(i) one or more of gap junction inhibitors selected from Gap 27 peptides, and (ii) one or more of choline acetyl transferase (CAT) inhibitors selected from the group consisting of plant extracts of stenolama chusana, portulaca oleracea, gynostemma pentaphyllum, and morinda citrifolia, wherein the total amount of said one or more gap junction inhibitors and said one or more choline acetyl transferase (CAT) inhibitors is between about 0.0001 wt % and about 50 wt % of the total weight of the composition and wherein said composition is applied in an amount and for a period of time sufficient to reduce the appearance of wrinkles on the skin.