Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma

摘要

The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I,;
wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and

wherein R is Cl and

wherein R may be located either in the para-, meta- or ortho-position of Ring A,

wherein S* is a sulphur atom that represents a chiral center,

and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

主权项

1. A method of making compound C wherein HX is tosylic acid, hydrochloric acid, or sulphuric acid, the method comprising: A) first contacting 4-cyano-piperidine with an acid and then reacting with ammonia in order to obtain intermediate E B) reacting intermediate E with compound D in the presence of a baseand
C) adding the acid HX to obtain compound C.