| 发明名称 | Human antibodies against tissue factor and methods of use thereof | ||
| 摘要 | Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies. | ||
| 申请公布号 | US9150658(B2) | 申请公布日期 | 2015.10.06 |
| 申请号 | US200913133811 | 申请日期 | 2009.12.09 |
| 申请人 | GENMAB A/S | 发明人 | Verploegen Sandra;Satijn David P. E.;Hoet Rene;Parren Paul;Van De Winkel Jan;Breinholt Vibeke Miller;Ehrnrooth Eva;Baadsgaard Ole;Vink Tom;Bleeker Willem Karel;Houtkamp Mischa;Oudshoorn Maroeska;De Jong Rob N. |
| 分类号 | C07K16/36;A61K39/395 | 主分类号 | C07K16/36 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Frank Christopher L. |
| 主权项 | 1. A human antibody which binds human Tissue Factor (TF), wherein said antibody: competes for TF binding with a reference antibody comprising a VH region comprising the sequence of SEQ ID NO:9 and a VL region comprising the sequence of SEQ ID NO:65, and does not compete for TF binding with a reference antibody comprising a VH region comprising the sequence of SEQ ID NO:37 and a VL region comprising the sequence of SEQ ID NO:93. | ||
| 地址 | Copenhagen DK | ||