| 主权项 |
1. A method of treatment of a cognitive or CNS disorder in a patient, wherein said disorder is one which is susceptible to treatment by a 3,7-diaminophenothiazine (DAPTZ) compound,
which method comprises orally administering to said patient a dosage unit containing at least 50 mg of said DAPTZ compound in stable crystalline reduced form as active ingredient, wherein said DAPTZ compound is selected from compounds of the following formulawherein:
each of R1 and R9 is independently selected from: —H; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid, wherein if any of HX1 and HX2 are hydrohalic acids, then each are independently selected from HCI or HBr; and wherein the patient has a haematological disorder selected from a haemoglobinopathy, an anemia, a haematological malignancy, and a coagulopathy. |
