Transdermal therapeutic system containing elongate hollow bodies

摘要

The invention relates to a transdermal therapeutic system for applying an active ingredient or several active ingredients to the skin. Elongate hollow bodies are incorporated into one of the layers of the TTS, said hollow bodies containing a filling medium or several filling mediums. The invention also relates to the production and use of said type of systems.

主权项

1. A transdermal therapeutic system (TTS) for delivering an active substance or more than one active substances, the transdermal therapeutic system comprising:
a backing that is impermeable to the active substance(s); a layer containing the active substance(s) or several layers containing the active substance(s); and optionally a detachable protective layer; wherein at least one layer containing the active substance(s) has physically distinct elongated hollow bodies each with a hollow space provided with a filler or several fillers, where the hollow space of each hollow body is noncontiguous with the hollow space of each other hollow body; wherein the elongated hollow bodies are configured so that the filler or fillers are only released from the hollow bodies by changing the structure of the hollow bodies; and wherein the elongated hollow bodies are incorporated in the at least one layer in the form of loose materials, and include at least one selected from the group consisting of hollow fibers, nanofibers, nanotubes, buckytubes, nano-scale carbon tubes, and carbon nanotubes.