| 发明名称 | Lipid vesicle compositions and methods of use | ||
| 摘要 | The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally. | ||
| 申请公布号 | US9149432(B2) | 申请公布日期 | 2015.10.06 |
| 申请号 | US201213400076 | 申请日期 | 2012.02.19 |
| 申请人 | Massachusetts Institute of Technology | 发明人 | Irvine Darrell J.;Moon Jaehyun |
| 分类号 | A61K9/127;A61K47/44;A61P33/06;C12N5/071;A61K39/015;A61K39/21;A61K39/39;A61K47/48;C07K14/005;C12N15/88;A61K39/00 | 主分类号 | A61K9/127 |
| 代理机构 | Wolf, Greenfield & Sacks, P.C. | 代理人 | Wolf, Greenfield & Sacks, P.C. |
| 主权项 | 1. A multilamellar lipid vesicle comprising a terminal-cysteine-bearing antigen, and having covalent crosslinks between lipid bilayers, wherein at least two lipid bilayers in the multilamellar lipid vesicle are covalently crosslinked to each other through headgroups that react with covalent crosslinkers to form the covalent crosslinks between lipid bilayers. | ||
| 地址 | Cambridge MA US | ||