Hormone Normalization Therapy and Uses Therefor

摘要

The present invention discloses methods of prevention of oocyte and fetal aneuploidy, birth defects, miscarriages and infertility in women. The three therapies, disclosed herein, the hormone normalization therapy, the aromatase inhibitor-hormone normalization therapy, and the low responder hormone normalization therapy with estrogenic supplementation focus on restoring young hormonal levels in women in order to prevent female infertility and miscarriages, guide follicular and oocyte maturation, follicular responsiveness, and promote correct chromosomal segregation in oocytes and early embryos.

主权项

1. A method for reducing the incidence of infertility by regulating levels of follicle stimulating hormone, luteinizing hormone, estradiol, and progesterone in a woman in need of such treatment, consisting of the steps of:
a) administering a gonadotropin releasing hormone or an agonist of gonadotropin releasing hormone or an antagonist of gonadotropin releasing hormone during the follicular and luteal phases (i) to reduce pituitary secretion of follicle stimulating hormone to about 4.5 IU/L or less and luteinizing hormone to about 5 IU/L or less and, (ii) to attenuate ovarian secretion of progesterone and estradiol such that endogenous levels of progesterone are about 5 nmol/L or less and endogenous levels of estradiol are about 150 pmol/L or less; b) administering follicle stimulating hormone during the follicular and luteal phases of the menstrual cycles until a pregnancy attempt; c) administering luteinizing hormone, human chorionic gonadotropin, progestagen, or a combination thereof for luteal phase support, d) repeating the steps a) to c) over at least 2 menstrual cycles prior to the pregnancy attempt, wherein said regulating is effective in said woman such that said levels of follicle stimulating hormone become similar to the varying serum levels of follicle stimulating hormone that are specific for each stage of the menstrual cycle in a young, fertile woman during the at least 2 menstrual cycles during which treatment is performed until the pregnancy attempt, thereby reducing the incidence of infertility in said woman.