发明名称 |
NEUTRALIZING RNA APTAMERS AGAINST PDGFBETA AND USES THEREOF IN THE THERAPY AND DIAGNOSIS OF HYPERPROLIFERATIVE DISEASES |
摘要 |
Nuclease-resistant RNA aptamers are provided which are capable of neutralizing PDGFRβ and are therefore useful in the diagnosis and/or therapy of PDGFRβ-associated and hyperproliferative-associated diseases, such as cancer and primary tumour metastasis. RNA aptamers provided herein include a modified synthetic RNA sequence wherein at least one pyrimidine residue is modified to 2′-fluoropyrimidine. Pharmaceutical compositions and diagnostic kits comprising RNA aptamers are also provided. |
申请公布号 |
US2015275215(A1) |
申请公布日期 |
2015.10.01 |
申请号 |
US201314433386 |
申请日期 |
2013.10.04 |
申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE |
发明人 |
Cerchia Laura;Condorelli Gerolama;De Franciscis Vittorio |
分类号 |
C12N15/115 |
主分类号 |
C12N15/115 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Roma IT |