| 发明名称 |
ONCOLYTIC RHABDOVIRUS |
| 摘要 |
Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo. |
| 申请公布号 |
US2015275185(A1) |
申请公布日期 |
2015.10.01 |
| 申请号 |
US201514696028 |
申请日期 |
2015.04.24 |
| 申请人 |
OTTAWA HOSPITAL RESEARCH INSTITUTE ;CHILDREN'S HOSPITAL OF EASTERN ONTARIO RESEARCH INSTITUTE INC. |
发明人 |
BELL John C.;STOJDL David F. |
| 分类号 |
C12N7/00;A61K45/06;A61K35/768;A61K35/766 |
主分类号 |
C12N7/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An attenuated rhabdovirus comprising:
a G protein having an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO:5 and an arginine at the position corresponding to position 242 of SEQ ID NO:5. |
| 地址 |
Ottawa CA |
