ANTI-MIGRATION AND ANTI-INVASION THIAZOLE ANALOGS FOR TREATMENT OF CELLULAR PROLIFERATIVE DISEASE

摘要

Thiazole analog compounds and their pharmaceutically acceptable salts are disclosed, including pharmaceutical compositions comprising the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, and/or with a pharmaceutically acceptable carrier. Methods of using the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative diseases, such as cancer, are also disclosed.

主权项

1. A compound of Formula (I) wherein R1 is thiophen-2-yl, furan-2-yl, 4-chlorophenyl, 4-bromophenyl, 3,4,5-trimethoxyphenyl, 3,4-dimethoxyphenyl, pyridin-3-yl, pyridin-4-yl, phenyl, cyclopentyl, cyclohexyl, n-pentyl, n-undecyl, phenyl, 4-methylphenyl, methoxyphenyl, dimethoxyphenyl at any two positions 2-6, trimethoxyphenyl at any three positions 2-6, C1-C20 alkyl, aryl, C3-C7 cycloalkyl, heterocyclyl, aryl (C1-C6 alkyl), or heterocyclyl (C1-C6 alkyl); R2 is hydrogen, methyl, ethyl, n-propyl, n-butyl, n-hexyl, n-dodecyl, C1-C12 alkyl, allyl, propynyl, or is absent; R3 is methyl, ethyl, n-propyl, n-butyl, n-hexyl, n-dodecyl, C1-C12 alkyl, allyl, propynyl, or is absent; R4 is hydrogen, methyl, tolyl, methoxyphenyl, C1-C12 alkyl, or aryl; R5 is hydrogen, —C(═O)— or —S(═O)2—; R6 hydrogen, methyl, cyclopropyl, phenyl, xylyl, chlorophenyl, bromophenyl, fluorophenyl, bis(trifluoromethyl)phenyl, trimethoxy phenyl, cyclopropyl, C2-C20 alkyl, C3-C7 cycloalkyl, aryl (C6-C10), or aromatic heterocyclyl (C5-C9); and the dashed lines represent optional double bonds; and wherein if R2 is absent, then the optional double bond between the amino nitrogen and position 2 of the thiazole ring is present; and if R3 is absent, then the optional double bond between positions 2 and 3 of the thiazole ring is present, or a salt thereof.